GENES The gene is a nucleic acid sequence that is necessary for function of gene product. Gene may be a protein coding gene whose transcribed RNA is translated into proteins or RNA only genes. Protein coding genes may be solitary or families or tandem repeats NON –CODING SEQUENCE The non coding sequence are genes that do not encode the protein. The amount of non-coding sequence in DNA of organism varies among species. Eg-Human genome -98% non-coding genes Prokaryotes -10% non-coding genes Types of Non coding sequences The non coding sequences can be in the form of following Introns Anti leader and Anti trailer sequence Promoter sequence Enhancers Pseudogenes Gene fragments Telomeres Non-coding functional RNA Cis-Trans regulatory elements INTRONS Introns are non-coding sequence that transcribed into RNA But precursor mRNA removed by splicing during processing. The eukaryotic genome has large amount of introns...
In this post going to see about PDH Complex
REGULATION
ATP GAINED
It is a multi enzyme complex.
OCCURRENCE
It is found in mitochondria.
DEFINITION
Pyruvate is converted to Acetyl Co A by oxidative decarboxylation catalysed by enzyme Pyruvate Dehydrogenase Complex.
ENZYMES
It has 3 enzymes
1.PYRUVATE DEHYROGENASE
2.DIHYDRO LIPOYL
3.DIHYDRO LIPOYL
TRANSACETYLASE
DEHYROGENASE
COFACTOR
1.TPP –Thiamine Pyro Phosphate
2.FAD+-Flavin Adenine Dinucleotide
3.CoA – Coenzyme A
4.Lipomide
5.NAD+ - Nicotinamide Adenine Dinucleotide
It is regulated by phosporylation and dehosphorylation.
Calicum stimulate PDH.
INHIBITORS
The NADH and Acetyl coA acts as inhibitor by end product inhibition
ENERGETICS
OVERALL REACTION
1.NAD+ +FADH2➡️ NADH+H+FAD+ = 3ATP
In next post we will see about Krebs cycle
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